Evaluation of Troponin-T level in Neonate with Mechanical Ventilation

Introduction: Troponin- T is the best biological marker of heart injuries, that isn&rsquo;t affected by sex, age, birth weight and gestational age. Myocardial damage in infancy is a risk factor eventual cardiac disease. This study carried out for cardiac evaluation of neonates with mechanical ventilation by Troponin T. Methods: This case-control study carried out on 60 infants that were admitted in neonate intensive care unit of Amir Almomenin hospital, Zabol, Iran. Neonates were enrolled in 2 groups: those who were supported with ventilator as cases and those who were not supported with ventilator as control group. We assayed the serum samples from neonates for Troponin T for myocardial injury. Data was analyzed using Pearson correlation, Mann-Whitney and Chi-square tests by SPSS software and significance level of 0.05. Results: Troponin T levels in case group was significantly different than it in control group at the beginning of the study and 24 hours after that (P<0.05). Generally, Troponin T level in case group was significantly higher than it in control group. Conclusion: We conclude that evaluation of newborn with mechanical ventilation enhances the possibility of occult and clinically myocardial injury. The results, in this study, suggest that Troponin T is a useful and early marker for myocardial injury.